HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → nepicastat hydrochloride anhydrous
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Nepicastat | HCID 9796181 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | nepicastat hydrochloride anhydrous | HCID 9840545 | — |
Reaction Steps
The (S)-5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydroimidazole-2-thione was dissolved in methanol and treated with 1.5 equivalents of anhydrous hydrogen chloride in ethyl ether. Removal of the solvents by co-evaporation with ethyl acetate gave (S)-5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydroimidazole-2-thione hydrochloride, m.p. 245° C., [α]D25 =11.30° (C=0.5, DMSO).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05538988 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-07f6460889bc4b51b82a9a27d4d206b9 |
| Source note | uspto-grants-1996_07 |