HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 1-(Chlorocarbonylmethyl)-N4-(benzyloxycarbonyl)cytosine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-(4-(((Benzyloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetic acid | HCID 725470 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Chlorocarbonylmethyl)-N4-(benzyloxycarbonyl)cytosine | HCID 23511184 | — |
Reaction Steps
Oxalyl chloride (6.3 g, 50 mmol) is added dropwise over 5 minutes to a solution of 1-(carboxymethyl)-N4 -(benzyloxycarbonyl)cytosine (15.3 g, 50 mmol) dissolved in dichloromethane (200 mL). The reaction is stirred until gas evolution has ceased and then for an additional 2 hours. The reaction mixture is evaporated to an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05539083 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-dd1fe011b3f141d8a4d0ccfbb1db2264 |
| Source note | uspto-grants-1996_07 |