2-(4-(4-Hydroxy-1-butenyl)phenyl)-5-decyloxypyrimidine → 2-(4-(4-Hydroxybutyl)-phenyl)-5-decyloxypyrimidine

Participants

Reaction Steps

0.38 g (1 mmol) of the thus obtained 2-(4-(4-hydroxy-1-butenyl)phenyl)-5-decyloxypyrimidine was dissolved in 20 ml of tetrahydrofuran, added with 0.05 g of 10% Pd/C and subjected to a hydrogenation reaction in a hydrogen atmosphere under normal pressure. The reaction was stopped when about 25 ml of hydrogen was consumed. Then 10% Pd/C was filtered out and the filtrate was concentrated to obtain 0.38 g of 2-(4-(4-hydroxybutyl)-phenyl)-5-decyloxypyrimidine (yield: 99%).

Provenance & Evidence