HCID 19694906, compound → HCID 19694910, compound

HRID 1735980Notes

Reaction equation

HRID 1735980 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]=[CH:14][C:13]([O:16][C:17]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[O:18])=[CH:12][N:11]=2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2]>C(Cl)(Cl)Cl>[OH:3][CH:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:15]=[CH:14][C:13]([O:16][C:17]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[O:18])=[CH:12][N:11]=2)=[CH:8][CH:9]=1)[CH3:2]

Participants

3

Reactant 1

HCID 19694906HCID 19694906, compound

Product 1

HCID 19694910HCID 19694910, compoundYield 33.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The procedure of Referential Example 11 was followed except for use of 38.3 g (0.1 mol) of 2-(4-acetylphenyl)-5-decylcarbonyloxypyrimidine in place of 35.5 g of 2-(4-acetylphenyl)-5-decyloxypyrimidine, forming an asymmetric hydrolyzate by use of an enzyme to obtain 13 g of (+)-2-(4-(1-hydroxyethyl)phenyl)-5-decylcarbonyloxypyrimidine (II-a-12), [α]D20 =+24.5° (c=1, chloroform).

Workup

  1. customforming an asymmetric hydrolyzate by use of an enzyme

Sources & evidence

ORD record
ord-03095fbb0a204012a3fa136a96134c5a
Source dataset
uspto-grants-1996_07
Patent number
US05539115

Reaction notes

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