1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 19434131, compound

Participants

Reaction Steps

A mixture of the product from Step B (3.67 g, 9.95 mmol), DBU (1.0 mL) and molecular sieves (1.5 g) in ethyl acetate (100 mL) was heated at reflux temperature for 4 h, cooled to room temperature, washed with 2N HCl (50 mL) and brine (50 mL), and dried (MgSO4). Evaporation of the solvent provided the desired ester (1.92 g) as an oil which was used without further purification.

Provenance & Evidence