N-bromobutanimide → HCID 15346987, compound

HRID 1736098Notes

Reaction equation

HRID 1736098 reaction equation
[NH2:1][C:2]1[C:7]2[C:8](=[O:19])[CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=3)[O:11][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Br:20]N1C(=O)CCC1=O>O1CCOCC1>[NH2:1][C:2]1[C:7]2[C:8](=[O:19])[CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=3)[O:11][C:6]=2[CH:5]=[CH:4][C:3]=1[Br:20]

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 10422310HCID 10422310, compound

Product 1

HCID 15346987HCID 15346987, compoundYield 4.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.50 g (11.9 mmol) of 5-amino-2-(4-aminophenyl)-4H-1-benzopyran-4-one (EP-A-374789) was dissolved in 75 ml of dioxane, 1.86 g (13.1 mmol) of N-bromosuccinimide was added and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure, and the residue was extracted with a mixed solution of chloroform and methanol. The extract was washed with an aqueous saturated solution of sodium chloride and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (chloroform:acetone=40:1) to give 170 mg (4.3%) of Compound 4.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. extractionthe residue was extracted with a mixed solution of chloroform and methanol
  3. washThe extract was washed with an aqueous saturated solution of sodium chloride
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationThe organic layer was concentrated under reduced pressure
  6. customthe residue was purified by silica gel column chromatography (chloroform:acetone=40:1)

Sources & evidence

ORD record
ord-9a1d734ab1f7400a8819e7f39584d180
Source dataset
uspto-grants-1996_07
Patent number
US05539112

Reaction notes

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