Triethylamine → HCID 51039312, compound

Participants

Reaction Conditions

Reaction Steps

7-Fluoro-2-(2-furyl)-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile (I-105) (40 mg, 0.13 mmol) was dissolved in anhydrous dimethyl sulfoxide (2 ml), and at room temperature, triethylamine (26 μl, 0.19 mmol) and (3S)-3-(dimethylamino)pyrrolidine (21 μl, 0.16 mmol) were added. This mixture liquid was stirred at 90° C. for 11 hours, then cooled to room temperature. This was fractionated with ethyl acetate and saturated brine. The aqueous layer was separated, and this was extracted twice with ethyl acetate.

Provenance & Evidence