HCID 19434931, compound → HCID 19434996, compound

Participants

Reaction Conditions

Reaction Steps

20 ml of concentrated sulfuric acid was added to the resulting 1.00 g (1.89 mmol) of 2-(4-amino-3,5-dibromophenyl)-6,8-difluoro-5-pivaloylamino-4H-1-benzopyran-4-one and the mixture was stirred at 100° C. for 1.3 hours. The reaction solution was adjusted to pH 9 by addition of ice and a 10N aqueous solution of sodium hydroxide thereto and the precipitated crystals were collected by filtration. The crystals were purified by silica gel column chromatography (chloroform:acetonitrile=40:1) and triturated with chloroform to give 378 mg (45%) of Compound 36.

Provenance & Evidence