HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 19434850, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Dimethylaminopyridine | HCID 21885 | — |
| Reactant | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| Reactant | 2-(4-Acetylamino-3-fluorophenyl)-5-amino-6,8-difluoro-4H-1-benzopyran-4-one | HCID 19434907 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19434850 | HCID 19434850 | 88% |
Reaction Steps
3.03 g (8.70 mmol) of Compound 27 obtained in Example 27 was dissolved in 200 ml of dimethylformamide, 109 mg of dimethylaminopyridine and 3.0 ml of di-tert-butyl carbonate were added and the mixture was stirred at room temperature for 2 hours. Water was added to the reaction solution and the precipitated crystals were collected by filtration to give 3.44 g (88%) of 2-[4-[N-acetyl-N-(tert-butoxycarbonyl)amino]-3-fluorophenyl]-5-amino-6,8-difluoro-4H-1-benzopyran-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05539112 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-3a0f7b2515604083bfec0b69c71a1b6a |
| Source note | uspto-grants-1996_07 |