Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Amino-2-(4-amino-3-fluorophenyl)-7-ethoxycarbonyl-6,8-difluoro-4H-1-benzopyran-4-one | HCID 10691034 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 10665515 | HCID 10665515 | 90.1% |
Reaction Steps
121 mg (0.320 mmol) of Compound 92 obtained in Example 92 (2) was suspended in a mixed solvent of 10 mL of ethanol and 5 mL of methanol, 0.4 mL of a 5N aqueous solution of sodium hydroxide was added and the mixture was stirred at 50° C. for 2.5 hours. The reaction solution was cooled on ice, the solution was adjusted to pH 4 and the precipitated crystals were collected by filtration to give 101 mg of Compound 93 (yield: 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05539112 |
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| Source dataset | uspto-grants-1996_07 |
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| ORD ID | ord-b4bc223093ed45058ac609a335d24e6d |
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| Source note | uspto-grants-1996_07 |
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