Sulfuric Acid → 2-(4-Amino-3-fluorophenyl)-5-(5-dimethylaminopentylamino)-6,8-difluoro-4H-1-benzopyran-4-one

Participants

Reaction Steps

Substantially the same manner as that in Example 127 (4) was repeated except that 909 mg (1.81 mmol) of the above 5-(5-dimethylaminopentylamino)-6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-4H-1-benzopyran-4-one was used, treatment with 15 mL of concentrated sulfuric acid was carried out and the resulting compound was recrystallized from ethyl acetate/n-hexane, to give 638 mg of Compound 139 (yield: 84%).

Provenance & Evidence