1-Propanol → HCID 19434964, compound

Participants

Reaction Conditions

Reaction Steps

582 mg (1.00 mmol) of 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methanesulfonyloxymethyl-5-pivaloylamino-4H-1-benzopyran-4-one obtained in EXAMPLE 120 (1) was dissolved in 100 mL of propanol, and the solution was stirred at 100° C. for 2 hours. The solvent was distilled off under reduced pressure to give the crude product of 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-7-propyloxymethyl-4H-1-benzopyran-4-one. This compound was used for the next step without further purification.

Provenance & Evidence