HCID 19434964, compound → HCID 10643350, compound

Participants

Reaction Conditions

Reaction Steps

The above 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-7-propyloxymethyl-4H-1-benzopyran-4-one was dissolved in 30 mL of a 50% aqueous solution of sulfuric acid, and the solution was stirred at 100° C. for 15 minutes. Then, the mixture was poured into ice-water and neutralized. The precipitate was collected and purified by silica gel column chromatography (chloroform:methanol=100:1) followed by recrystallization from ethyl acetate/n-hexane, to give 286 mg of Compound 150 (yield: 76%).

Provenance & Evidence