Pyridine → HCID 12266212, compound

HRID 1736255Notes

Reaction equation

HRID 1736255 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6](=[O:9])[CH2:7][Br:8])=[CH:4][CH:3]=1.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CC(C)=O>[Br-:8].[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6](=[O:9])[CH2:7][N+:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 1049PyridineHCID 692722-Bromo-4'-methylacetophenone

Product 1

HCID 12266212HCID 12266212, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
60 °C

Procedure

64 g (0.3 mol) of 4-methylphenacyl bromide in 80 ml acetone were initially taken and heated to 60° C. 24 g (0.3 mol) of pyridine were then slowly added dropwise. The reaction mixture was stirred for a further hour at 60° C. and cooled to room temperature. The precipitated solid was filtered off and washed with acetone. After drying, 82.5 g (corresponding to a yield of 94%) of the title compound were obtained in the form of a yellow powder. The purity of the product was more than 99%.

Workup

  1. temperaturecooled to room temperature
  2. filtrationThe precipitated solid was filtered off
  3. washwashed with acetone
  4. customAfter drying

Sources & evidence

ORD record
ord-c5ce42010f0d45f6b4eb775af1ed13f5
Source dataset
uspto-grants-1996_07
Patent number
US05541032

Reaction notes

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