HCID 10615563, compound → HCID 19417465, compound

HRID 1736337Notes

Reaction equation

HRID 1736337 reaction equation
OCC1C2SC(S)=NC=2C=CC=1.[F:13][C:14]([S:17]([O-:20])(=[O:19])=[O:18])([F:16])[F:15].[C:21]([CH2:24][N+:25]12[CH2:32][CH2:31][N:28]([CH2:29][CH2:30]1)[CH2:27][CH2:26]2)(=[O:23])N>>[F:13][C:14]([S:17]([O-:20])(=[O:19])=[O:18])([F:16])[F:15].[OH:23][CH2:21][CH2:24][N+:25]12[CH2:32][CH2:31][N:28]([CH2:27][CH2:26]1)[CH2:29][CH2:30]2

Participants

3

Reactant 2

HCID 10615563HCID 10615563, compoundHCID 178519445HCID 178519445, compound

Product 1

HCID 19417465HCID 19417465, compound

Procedure

Starting with the product of Example 5, Step 2 (64 mg) and following the procedure of Example 4, Step 3, but substituting 1-carbamoylmethyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethylsulfonate, with 1-(2-hydroxyethyl)-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethylsulfonate one obtains the desired product (76.4 mg).

Sources & evidence

ORD record
ord-0626c93588ab4bdfa88eb0d160122d11
Source dataset
uspto-grants-1996_07
Patent number
US05541176

Reaction notes

Loading…