(S)-mandelic acid → HCID 131719470, compound

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Reaction Steps

A mixture of 4.28 g 3-amino-1,3-dihydro-1-(3-methyl-2-thenoyl)methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, 1.59 g (S)-mandelic acid, 63 mg 3,5-dichlorosalicylaldehyde and 110 ml acetonitrile was stirred at room temperature for three days. The crystals which separated out were collected by filtration and washed with 100 ml acetonitrile, thus giving 5.13 g of (R)-3-amino-1,3-dihydro-1-(3-methyl-2-thenoyl)methyl-5-phenyl-2H-1,4-benzodiazepin-2-one·(S)mandelate as white crystals.

Provenance & Evidence