(S)-mandelic acid → HCID 131719471, compound

Participants

Reaction Steps

To a solution of 2.75 g 3-amino-1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one in 55 ml acetonitrile, was added 0.98 g (S)(+)-mandelic acid, the mixture was stirred at room temperature for 30 minutes, 41 mg 3,5-dichlorosalicylaldehyde was then added, and stirring was further continued for 18 hours. The crystals which separated out were collected by filtration and washed with 15 ml acetonitrile, thus giving 2.94 g of (R)-3-amino-1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one·(S)-mandelate.

Provenance & Evidence