m-Tolyl isocyanate → HCID 10767780, compound

Participants

Reaction Steps

To a mixture of 0.74 g 3-amino-1,3-dihydro-1-phenacyl-5-phenyl-2H-1,4-benzodiazepin-2-one and 5 ml tetrahydrofuran, was added a solution of 0.27 g 3-tolyl isocyanate in 3 ml tetrahydrofuran, and the resulting mixture was stirred at room temperature for four hours. The solvent was distilled off from the reaction mixture, and the residue was recrystallized from a mixture of toluene and n-hexane, thus giving 0.78 g of 1-[2,3-dihydro-2-oxo-1-phenacyl-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-tolyl)urea.

Provenance & Evidence