m-Tolyl isocyanate → HCID 19432592, compound

Participants

Reaction Steps

A mixture of 0.26 g 3-amino-1,3-dihydro-5-phenyl-1-(2-thenoyl)methyl-2H-1,4-benzodiazepin-2-one, 95 mg 3-tolylisocyanate and 5 ml tetrahydrofuran was stirred at room temperature for two hours. The solvent was distilled off from the reaction mixture under reduced pressure, a 1:1 mixture of toluene and diethyl ether (5 ml) was added to the residue, and the crystals were collected by filtration, thus giving 0.2 g of 1-[2,3-dihydro-2-oxo-5-phenyl-1-(2-thenoyl)methyl-1H-1,4-benzodiazepin-3-yl]-3-(3-tolyl)urea.

Provenance & Evidence