Nitric Acid → HCID 19432542, compound

HRID 1736372Notes

Reaction equation

HRID 1736372 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[C:10]=1[OH:11])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 198603-Chloro-4-hydroxybenzoic acid

Product 1

HCID 19432542HCID 19432542, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

Sulphuric acid (83%, 20 ml) was cooled in an ice-bath, and 3-chloro-4-hydroxybenzoic acid (4 g, 22 mM) stirred in. After 10 minutes, nitric acid (70%, 1.43 ml, 22 mM) was run in, and the mixture stirred at 0° for 2 hours. After pouring onto ice, the solid was filtered, and recrystallised from aqueous ethanol to give title compound as yellow crystals (2.1 g, 44%).

Workup

  1. additionAfter pouring onto ice
  2. filtrationthe solid was filtered
  3. customrecrystallised from aqueous ethanol

Sources & evidence

ORD record
ord-e99957122c7a438b962e9c7de6f73ac7
Source dataset
uspto-grants-1996_07
Patent number
US05541178

Reaction notes

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