3-Isocyanatopyridine → HCID 70347305, compound

Participants

Reaction Conditions

Reaction Steps

57 mg of 3-pyridyl isocyanate were added to 121.5 mg of N-[5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-pyrimidin-4-yl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide dissolved in 1 ml of dry toluene. The reaction mixture was stirred at 100° C. for 1 hour. Then, the solution was added to a silica gel column and it was eluted with EtOAc. There was obtained pyridin-3-ylcarbamic acid 2-[5-(2-chloro-5-methoxy -phenoxy]-6-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonylamino) -pyrimidin-4-yloxy]-ethyl ester, white powder, MS: m/e =630.4 (M+H)+.

Provenance & Evidence