HRID1736393

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21885

2-Dimethylaminopyridine

C7H10N2

HCID84810

4-Morpholinecarbonyl chloride

C5H8ClNO2

结构：COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1

HCID122044

Ro 46-2005

C23H27N3O6S

PRODUCTS

生成物

结构：COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOC(=O)N2CCOCC2)c1

HCID54072965

未命名化合物

PROCEDURE

实验过程

In analogy to Example 1, part a), from 0.15 ml of morpholine-4-carbonyl chloride and 200 mg of p-tert-butyl-N-[6-(2-hydroxy-ethoxy) -5-(m-methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide with the addition of 154 mg of dimethylaminopyridine at a reaction period of 12 hours there was obtained morpholine-4-carboxylic acid 2-[6-(4-tert -butyl-phenylsulfonylamino)-5-(3-methoxy-phenoxy)-pyrimidin-4-yloxy]-ethyl ester. MS: 587.4 (M+H).

WORKUP

后处理

customat a reaction period of 12 hours there

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b54aaf3a09f043688c195c0eb7a46914
来源数据集: uspto-grants-1996_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05541186
来源说明: uspto-grants-1996_07

反应 SMILES

[N:1]1([C:7](Cl)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:10]([C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:23][C:24]2[C:29]([O:30][C:31]3[CH:36]=[CH:35][CH:34]=[C:33]([O:37][CH3:38])[CH:32]=3)=[C:28]([O:39][CH2:40][CH2:41][OH:42])[N:27]=[CH:26][N:25]=2)(=[O:22])=[O:21])=[CH:16][CH:15]=1)([CH3:13])([CH3:12])[CH3:11].CN(C1C=CC=CN=1)C>>[C:10]([C:14]1[CH:15]=[CH:16][C:17]([S:20]([NH:23][C:24]2[N:25]=[CH:26][N:27]=[C:28]([O:39][CH2:40][CH2:41][O:42][C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])[C:29]=2[O:30][C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([O:37][CH3:38])[CH:32]=2)(=[O:22])=[O:21])=[CH:18][CH:19]=1)([CH3:13])([CH3:11])[CH3:12]