反应详情

By brominating 4,6-dichloro-5-(3-methoxyphenoxy)-pyrimidine with N-bromosuccinimide in acetic acid/acetic anhydride at 100° C. there was obtained 4,6-dichloro-5-(2-bromo-5-methoxyphenoxy)pyrimidine; therefrom with p-tert-benzenesulfonamide K there was obtained N-[5-(2-bromo-5-methoxyphenoxy)-6-chloropyrimidin-4-yl]-4-tert-butyl -benzenesulfonamide and therefrom with Na ethylene glycolate there was obtained p-tert-butyl-N-[5-(2-bromo-5-methoxyphenoxy)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-benzenesulfonamide.

1. customat 100° C.