HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(4-nitrophenyl)-2-hydroxy-N-(2-aminoethyl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Atrolactic acid | HCID 1303 | — |
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | Methyl-p-nitrophenyl lactate | HCID 56998982 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 3-(4-nitrophenyl)-2-hydroxy-N-(2-aminoethyl)propionamide | HCID 19360733 | — |
Reaction Steps
Phenyl-lactic acid (available from Aldrich Chemical Co., Milwaukee, Wis.) is nitrated with nitric acid in sulfuric acid. P-nitrophenyl lactic acid is esterified with methanol and gaseous hydrochloric acid. Methyl-p-nitrophenyl lactate is condensed with ethylene diamine to provide the amide adduct, 3-(4-nitrophenyl)-2-hydroxy-N-(2-aminoethyl)propionamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05541287 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-dece0327f6aa4919af6373be82640116 |
| Source note | uspto-grants-1996_07 |