Deoxyadenosine → HCID 53939218, compound

Participants

Reaction Steps

2'-Deoxyadenosine was conveniently transformed into 5'-O-tert-butyldiphenylsilyl-2',3'-dideoxy-3'-C-styryladenosine in 60% yield utilizing the radical reaction described in Example 82 of application Ser. No. 08/040,903. The 5'-O-TBDPS group of the latter compound was deblocked to provide 2',3'-dideoxy-3'-C-styryladenosine in 91% yield, mp 215°-217° C. Anal.: C18H19N5O2.1/4 H2O Calcd.: C% 63.23; H% 5.74; N% 20.48; Found: C% 63.31; H% 5.68; N% 20.69.

Provenance & Evidence