Ethyl 4'-[(2-n-butyl-7-n-propylamino-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate → 4'-[(2-n-Butyl-7-n-propylamino-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid

HRID 1736817Notes

Reaction equation

HRID 1736817 reaction equation
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[C:18]([C:23]([O:25]CC)=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:13][CH:12]=2)[C:8]2[C:28]([NH:32][CH2:33][CH2:34][CH3:35])=[CH:29][CH:30]=[CH:31][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+].C(O)C>>[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[C:18]([C:23]([OH:25])=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:15][CH:16]=2)[C:8]2[C:28]([NH:32][CH2:33][CH2:34][CH3:35])=[CH:29][CH:30]=[CH:31][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 15069416Ethyl 4'-[(2-n-butyl-7-n-propylamino-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylateHCID 23692425Sodium hydroxide ethanol

Product 1

HCID 150693894'-[(2-n-Butyl-7-n-propylamino-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid

Procedure

Prepared in analogous manner to Example 72 from ethyl 4'-[(2-n-butyl-7-n-propylamino-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate and 2N sodium hydroxide/ethanol.

Sources & evidence

ORD record
ord-684400f853ac4e5c9add24eaad01901f
Source dataset
uspto-grants-1996_07
Patent number
US05541229

Reaction notes

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