2-Chlorobenzoic Acid → HCID 57317527, compound

Participants

Reaction Steps

200 mg (0.467 mmol) of (2R*,4S*)-2-benzyl-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine are reacted in analogy to Example 4a with 88 mg (0.560 mmol) of 2-chlorobenzoic acid, 143 mg (0.561 mmol)of bis-(2-oxo-3-oxazolidinyl)phosphinic chloride and 144 μl (1.03 mmol) of triethylamine. The title compound (179 mg, 68%) is obtained as white foam. TLC: methylene chloride/methanol/conc. ammonia (2000:50:1) Rf =0.42, FD-MS: M+ =565, 567.

Provenance & Evidence