Indole-3-Carboxaldehyde → HCID 57235526, compound

Participants

Reaction Steps

200 mg (0.55 1 mmol) of (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-4-piperidinamine are reacted in analogy to Example 2g with 80 mg (0.551 mmol) of indole-3-carboxaldehyde and 90 mg of magnesium sulfate in 2 ml of toluene and subsequently reduced with 22 mg (0.584 mmol) of sodium borohydride in 2 ml of methanol. The title compound ##STR96## is obtained (75 mg, 28%) as white foam. TLC: methylene chloride/methanol/conc. ammonia (400:50:1) Rf =0.49, FD-MS: M+ =491,493. IR: 3460, 1630 cm-1.

Provenance & Evidence