HRID1737091

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

结构：CC(C)[C@H](NC(=O)CNC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)OC(C)(C)C)C(C)C

HCID18655610

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@H](NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CN)C(C)C

HCID18655613

未命名化合物

收率 91%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Using the procedure of Example 6F but replacing the resultant compound of Example 6E with the resultant compound of Example 140 provided, after silica gel chromatography using 10% methanol in dichloromethane, 48.7 mg (91%) of the desired compound as a white solid. 1H NMR (DMSO-d6) δ 0.70-0.83 (four d, 12H), 1.78 (m, 1H) , 1.96 (m, 1H), 2.62 (m, 2H) , 2.74 (br d, 2H), 2.97 (m, 1H), 3.46-3.87 (m, 5H), 4.02 (m, 2H), 4.21 (m, 1H), 5.33 (br d, 1H), 7.08-7.26 (m, 10H), 7.57(br d, 2H), 7.67 (br d, 1H), 7.86 (br d, 1H). Mass spectrum: (M+H)+ =583.

WORKUP

后处理

customprovided

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eea94a825750435d87ee0de95d08bd36
来源数据集: uspto-grants-1996_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05541334
来源说明: uspto-grants-1996_07

反应 SMILES

C([NH:8][CH2:9][C:10]([NH:12][C@H:13]([C:17]([NH:19][C@H:20]([CH:28]([OH:56])[C@@H:29]([NH:37][C:38](=[O:55])[C@H:39]([CH:52]([CH3:54])[CH3:53])[NH:40][C:41](=[O:51])[CH2:42][NH:43]C(OC(C)(C)C)=O)[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:18])[CH:14]([CH3:16])[CH3:15])=[O:11])(OC(C)(C)C)=O.CO>ClCCl>[NH2:8][CH2:9][C:10]([NH:12][C@H:13]([C:17]([NH:19][C@H:20]([CH:28]([OH:56])[C@@H:29]([NH:37][C:38](=[O:55])[C@H:39]([CH:52]([CH3:54])[CH3:53])[NH:40][C:41](=[O:51])[CH2:42][NH2:43])[CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:18])[CH:14]([CH3:15])[CH3:16])=[O:11]