Sodium Hydroxide → HCID 178442477, compound

Participants

Reaction Steps

Sodium hydroxide solution (1M; 100 ml) was added to a solution of 2-ethanoyloxy-3-(3,3-dimethylbutyl)-naphthalene-1,4-dione (3.5 g)(see Example 44) in THF (100 ml) at room temperature and stirred for 4 hours. The THF was removed under vacuum and the resultant solution was washed with diethyl ether (3x). The aqueous layer was acidified then extracted with diethyl ether (x3), the combined extracts washed with water, dried over magnesium sulphate then evaporated to dryness under vacuum to yield 3 g title compound.

Provenance & Evidence