Ammonia → L-Aspartic Acid

HRID 1737162Notes

Reaction equation

HRID 1737162 reaction equation
[C:1]([O-:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([O-:6])=[O:5].[C:9]([OH:16])(=[O:15])/[CH:10]=[CH:11]\[C:12]([OH:14])=[O:13].[NH3:17].C([O-])(=O)/C=C\C([O-])=O.[NH4+].[NH4+]>>[NH2:17][C@H:2]([C:1]([OH:8])=[O:7])[CH2:3][C:4]([OH:6])=[O:5].[C:9]([OH:16])(=[O:15])/[CH:10]=[CH:11]\[C:12]([OH:14])=[O:13]

Participants

6

Reactant 4

HCID 222AmmoniaHCID 444266Maleic AcidHCID 5288227Maleate(2-)HCID 10997209Diammonium maleate

Product 2

HCID 5960L-Aspartic AcidHCID 444266Maleic Acid

Procedure

Still alternatively, both an immobilized biocatalyst with immobilized cells containing maleate isomerase and an immobilized catalyst with immobilized cells containing aspartase are combined and packed into a column and an aqueous solution of maleic acid and ammonia or an aqueous solution of ammonium maleate is passed through the column, to produce L-aspartic acid by a single-step process from maleic acid.

Workup

  1. additionan immobilized catalyst with immobilized cells containing aspartase

Sources & evidence

ORD record
ord-0226c9a820a94e87864fcbb7c8d39811
Source dataset
uspto-grants-1999_10
Patent number
US05962280

Reaction notes

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