Dimethylformamide → HCID 88308980, compound

Participants

Reaction Steps

To a solution of 25 mL of N,N-dimethylformamide containing 0.11 g of the title compound of Step D under a nitrogen atmosphere was added 0.17 g of potassium carbonate and 0.11 g of 3-chloro-7-methoxy-1,2,4-benzotriazine 1-oxide. The reaction mixture was stirred at room temperature for approximately 24 h, and was then poured into water and extracted with dichloromethane. The organic extracts were washed with water and saturated aqueous sodium chloride. The organic layer was dried over magnesium sulfate, filtered and the filtrate was then evaporated to obtain a yellow oil. The yellow oil was crystallized from 1-chlorobutane/hexane to yield 0.11 g of the title compound of Step E, a compound of the invention, as a yellow solid melting at 191-192° C. 1H NMR (400 MHz, CDCl3): δ 3.250 (s,3H), 3.827 (s,3H), 3.964 (s,3H), 7.4-7.52 (m,5H), 7.65 (d,1H), 7.723 (d,1H).

Provenance & Evidence