HCID 2302295, compound → HCID 13583849, compound

HRID 1737222Notes

Reaction equation

HRID 1737222 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[NH2:18].[CH:19]([O-])([O-])[O:20]C(Cl)(Cl)Cl>C1(C)C=CC=CC=1>[N:18]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[O:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)=[C:19]=[O:20]

Participants

4

Reactant 2

HCID 2302295HCID 2302295, compoundHCID 131721392HCID 131721392, compound

Product 1

HCID 13583849HCID 13583849, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of the title compound of Step B (7.6 g, 32.3 mmol) in 150 mL of toluene was added trichloromethyl orthoformate (6.40 g, 32.3 mmol) at room temperature. The resultant mixture was then heated at reflux overnight. The reaction mixture was then concentrated under reduced pressure to yield the title compound of Step C as an oil which was then used entirely in Step D.

Workup

  1. temperatureat reflux overnight
  2. concentrationThe reaction mixture was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-780293c2368f4fd4927fd8b8f21f5f48
Source dataset
uspto-grants-1999_10
Patent number
US05962436

Reaction notes

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