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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1737247Generated: October 31, 2026

Citric Acid → Guaifenesin

https://huagongshe.com/reaction/1737247

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCitric AcidHCID 311—
ReactantD-(-)-FructoseHCID 5984—
ReactantTrisodium citrateHCID 6224—
ProductGuaifenesinHCID 3516—

Reaction Steps

The maltitol was similarly admixed with Phase F to form Phase G to which the ammonium glycyrrhizinate was added with another about 5 minutes mixing time being used. The flavors and colorants were then admixed, with a mixing time of about 5 minutes, followed by addition of a sufficient amount of liquid fructose to make the desired volume and mixing to homogeneity. The pH value was thereafter adjusted to be between 4 and 5 using a citric acid or sodium citrate solution. This composition provides 100 mg of guaifenesin per 5 mL (teaspoon).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05962461
Source datasetuspto-grants-1999_10
ORD IDord-d33748d6f5bf4c18bd27a2bf59aa6896
Source noteuspto-grants-1999_10