反应详情

A mixture of 3-aminopyrazine-2-carboxylic acid o-toluamide (1.0 g, 4.39 mmol) and acetic anhydride (12 mL) was refluxed 2 hours. The solvent was removed and the residue was triturated with hot ethyl acetate. The ethyl acetate slurry was cooled and the product was collected and rinsed with ether to afford 0.893 g (76%) of 3-acetamidopyrazine-2-carboxylic acid o-toluamide.

1. temperaturewas refluxed 2 hours
2. customThe solvent was removed
3. customthe residue was triturated with hot ethyl acetate
4. temperatureThe ethyl acetate slurry was cooled
5. customthe product was collected
6. washrinsed with ether