3-Nitrophenyl isocyanate → HCID 22879316, compound

HRID 1737280Notes

Reaction equation

HRID 1737280 reaction equation
[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[C:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[N:11][C@@H:10]([NH:25][C:26]([NH:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31](C)[CH:30]=2)=[O:27])[C:9]1=[O:36])=[O:6])([CH3:4])([CH3:3])[CH3:2].[N+:37](C1C=C(N=C=O)C=CC=1)([O-:39])=[O:38]>>[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[C:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[N:11][C@@H:10]([NH:25][C:26]([NH:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([N+:37]([O-:39])=[O:38])[CH:30]=2)=[O:27])[C:9]1=[O:36])=[O:6])([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 768353-Nitrophenyl isocyanateHCID 10322988HCID 10322988, compound

Product 1

HCID 22879316HCID 22879316, compoundYield 94%

Procedure

The resolved aminobenzodiazepine of Example 26 was treated with m-nitrophenyl isocyanate as described in Example 45 to provide a colourless oil (490 mg, 94%).

Sources & evidence

ORD record
ord-5089b2b583fa4d18b99af7154d8ca65a
Source dataset
uspto-grants-1999_10
Patent number
US05962451

Reaction notes

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