HCID 21842038, compound → HCID 86754566, compound

HRID 1737282Notes

Reaction equation

HRID 1737282 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:12]([CH:15]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][O:26][CH3:27])=[CH:20][CH:19]=2)[CH2:16][CH3:17])[CH2:13][CH3:14])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][O:10][CH3:11].[CH3:28][O:29][P:30]([O:50][CH3:51])([C:32]([P:44]([O:48][CH3:49])([O:46][CH3:47])=[O:45])([O:39][Si:40]([CH3:43])([CH3:42])[CH3:41])[CH2:33][CH2:34][CH2:35][C:36](O)=[O:37])=[O:31]>>[CH3:49][O:48][P:44]([O:46][CH3:47])([C:32]([P:30]([O:29][CH3:28])([O:50][CH3:51])=[O:31])([O:39][Si:40]([CH3:42])([CH3:41])[CH3:43])[CH2:33][CH2:34][CH2:35][C:36]([NH:1][C:2]1[CH:3]=[C:4]([CH:12]([CH:15]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH2:25][O:26][CH3:27])=[CH:22][CH:23]=2)[CH2:16][CH3:17])[CH2:13][CH3:14])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][O:10][CH3:11])=[O:37])=[O:45]

Participants

3

Reactant 2

HCID 21842038HCID 21842038, compoundHCID 56992283HCID 56992283, compound

Product 1

HCID 86754566HCID 86754566, compound

Procedure

Erythro 3-(3-(5,5-bis(dimethoxyphosphinoyl)-5-trimethylsilyloxybutyrylamino)-4-methoxymethoxyphenyl)-4-(4-methoxymethoxyphenyl)hexane (1.17 g, quantitative yield) was obtained in the same manner as in Example 4 except for using erythro 3-(3-amino-4-methoxymethoxyphenyl)-4-(4-methoxymethoxyphenyl)hexane (560 mg) obtained by the process described in Reference Example 4 and 5,5-bis(dimethoxyphosphinoyl)-5-trimethylsilyloxyvaleric acid (1 equivalent per equivalent of the former) obtained by the process described in Reference Example 31.

Workup

  1. customobtained by the process
  2. customobtained by the process

Sources & evidence

ORD record
ord-95c1d499777b4a13bf11fd926289aae3
Source dataset
uspto-grants-1999_10
Patent number
US05962438

Reaction notes

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