184906-26-1 → HCID 10655861, compound

Participants

Reaction Steps

Imine 38 (1.00 g, 4.93 mmol) is hydrogenated (50 psi H2) over RaNi (spatula scoop, washed 3×with water and 3×with EtOH) in EtOH (20 mL) for 2 h at rt. Filtration of the reaction mixture through filter aid and evaporation of the solvent gives the amine as a light yellow solid (MW=205.3) which is used without further purification. Yield: 0.90 g (89%) . 1H NMR (CDCl3) 6.68 (s, 1), 3.95 (s, 2), 3.62 (br s, 2), 2.45 (s, 2), 2.21 (s, 3), 2.08 (s, 3), 1.20 (s, 6); 13C NMR (CDCl3) 150.43, 131.39, 125.87, 125.12, 122.19, 121.16, 48.85, 43.93, 38.98, 27.89, 16.01, 10.97.

Provenance & Evidence