Ethyl isobutyrate → HCID 10846227, compound

Participants

Reaction Steps

Ethyl isobutyrate (10.9 mL, 81.7 mmol) is alkylated with 2-(chloromethyl)thiophene according to general procedure F to give the product 44 as a yellow liquid (16.4 g, 95%). 1H NMR (CDCl3) 7.15-7.10 (m, 1), 6.95-6.90 (m, 1), 6.77 (d, 1, J=3.6), 4.15 (t, 2, J=7.0), 3.07 (s, 2), 1.26 (t, 3, J=7.0), 1.21 (s, 6); 13C NMR (CDCl3) 176.96, 139.80, 126.74, 126.42, 123.94, 60.59, 43.65, 40.30, 25.07, 14.22; MS (MW=212.3, CI/CH4, eE=70 eV) m/z 213 [(M+H)30 , base peak], 193, 179, 167, 140, 139, 125, 98, 97.

Provenance & Evidence