Hydrochloric Acid → HCID 86753940, compound

Participants

Reaction Steps

1.09 g (0.00269 mol) of (S)-1-(5-dipropylaminomethyl-oxazol-2-yl)-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepin-9-one in 20 ml of ethyl acetate were treated with 0.80 ml (0.00296 mol) of 3N ethanolic hydrochloric acid at 0°. After stirring at 0° for 1 hr. the white suspension was suction filtered. The beige crystals were recrystallized from hot acetonitrile. There was obtained 0.71 g (60%) of (S)-1-(5-dipropylaminomethyl-oxazol-2-yl)-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepin-9-one hydrochloride (1:1) as light yellowish crystals; m.p. 227-230° and [α]D20 =-168.8° (MeOH, c=1%).

Provenance & Evidence