Hydrochloric Acid → HCID 21842274, compound

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Reaction Steps

1.2 g (0.0028 mol) of 7-chloro-3-(5-dipropylaminomethyl-oxazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 80 ml of ethyl acetate were treated at 0° with 0.84 ml (0.0031 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 15 minutes the white suspension was suction filtered. The yellowish crystals were dissolved in hot acetonitrite and recrystallized by the addition of ether. There were obtained 1.03 g (79%) of 7-chloro-3-(5-dipropylaminomethyl-oxazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 218-210° (dec.).

Provenance & Evidence