2-Azetidinecarboxylic acid, (S)- → HCID 54065826, compound

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Reaction Steps

A solution of 26.9 g (0.171 mol) of 2H-thieno-[3,2-d][1,3]oxazine-2,4(1H)-dione and 16.1 g (0.171 mol) of L-azetidine-2-carboxylic acid in 200 ml of dimethylformamide and 40 ml of acetic acid was stirred at 120° for 3 hrs. The brown solution was evaporated and the brown residue obtained was crystallised from ethanol. There were obtained 15.2 g (43%) of (S)-6,7-dihydroazeto[1,2-a]thieno[3,2-e][1,4]diazepine-5,9(4H,5aH)-dione as colourless crystals; m.p. 274°.

Provenance & Evidence