Hydrochloric Acid → HCID 86753950, compound

Participants

Reaction Steps

0.23 g (0.00062 mol) of (S)-1-(5-propylaminomethyl-oxazol-2-yl)-11,11a-dihydro-8H,10H-azeto[1,2-a]imidazo[5,1-c]thieno[3,2-e][1,4]diazepin-8-one in 15 ml of ethanol was treated with 0.18 ml (0.00065 mol) of 3.7N ethanolic hydrochloric acid. The yellow solution was concentrated to 5 ml and treated with 15 ml of ethyl acetate. After stirring at 0° for 1/2 hr. the suspension was suction filtered. There was obtained 0.19 g (76%) of (S)-1-(5-propylaminomethyl-oxazol-2-yl)-11,11a-dihydro-8H,10H-azeto[1,2-a]imidazo[5,1-c]thieno[3,2-e][1,4]diazepin-8-one hydrochloride (1:1) as white crystals; m.p. 218-220° (dec.) and [α]D20 =-285.3° (H2O, c=3%).

Provenance & Evidence