Hydrochloric Acid → HCID 86753952, compound

Participants

Reaction Steps

0.92 g (0.00224 mol) of (S)-1-(5-dipropylaminomethyl-oxazol-2-yl)-11,11a-dihydro-8H,10H-azeto[1,2-a]imidazo[5,1-c]thieno[3,2-e][1,4]diazepin-8-one in 50 ml of ethyl acetate was treated with 0.67 ml (0.00246 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1/2 hr. the suspension was suction filtered. The yellowish crystals were dissolved in hot acetonitrile and recrystallized by the addition of ether. There was obtained 0.88 g (88%) of (S)-1-(5-dipropylaminomethyl-oxazol-2-yl)-11,11a-dihydro-8H,10H-azeto[1,2-a]imidazo[5,1-c]thieno[3,2-e][1,4]diazepin-8-one hydrochloride (1:1) as whitish crystals; m.p. 233-236° (dec.) and [α]D20 =-29.2° (H2O, c=1%).

Provenance & Evidence