Chloroform → 4-(3-Chloropropyl)pyridyl hydrochloride

HRID 1737471Notes

Reaction equation

HRID 1737471 reaction equation
S(Cl)([Cl:3])=O.[N:5]1C=[CH:9][C:8]([CH2:11][CH2:12][CH2:13]O)=[CH:7][CH:6]=1.Cl[CH:16]([Cl:18])Cl>>[Cl:3][CH2:13][CH2:12][CH2:11][C:8]1[CH:7]=[CH:6][N:5]=[C:16]([Cl:18])[CH:9]=1

Participants

4

Reactant 3

HCID 6212ChloroformHCID 24386Thionyl ChlorideHCID 729234-Pyridinepropanol

Product 1

HCID 865846804-(3-Chloropropyl)pyridyl hydrochloride

Conditions

Temperature
0 °C

Procedure

Thionyl chloride (1.6 ml) was added to a solution of 4-pyridine propanol (2 g, 14.5 mmol) in trichloromethane (20 ml) cooled at 0° C. After stirring for 1 hour at ambient temperature followed by 1 hour at 60° C., the solvent was evaporated and the residue was triturated with ether to give 4-(3-chloropropyl)pyridyl hydrochloride as a white solid.

Workup

  1. waitfollowed by 1 hour at 60° C.
  2. customthe solvent was evaporated
  3. customthe residue was triturated with ether

Sources & evidence

ORD record
ord-0e93481d82834c23a36c19b53aef5714
Source dataset
uspto-grants-1999_10
Patent number
US05962458

Reaction notes

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