HuagongsheHuagongshe Chemistry Print Report · For research reference only
Picolyl chloride hydrochloride → HCID 22625043, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Picolyl chloride hydrochloride | HCID 23392 | — |
| Reactant | 4-(4-Chloro-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline | HCID 135513720 | — |
| Product | HCID 22625043 | HCID 22625043 | 35.5% |
Reaction Steps
Using an analogous procedure to that described in Example 38, 4-(4-chloro-2-fluoroanilino)-7-hydroxy-6-methoxyquinazoline (319.5 mg, 1 mmol), (prepared as described for the starting material in Example 24), was reacted with 2-(chloromethyl)pyridine hydrochloride (310 mg, 1.9 mmol) to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-((2-pyridyl)methoxy)quinazoline (146 mg, 33%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05962458 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-af38abbd40854d5eb72611aa10ed55f8 |
| Source note | uspto-grants-1999_10 |