反应详情

To a solution of 1.2 gm (21.4 mMol) potassium hydroxide in 12 mL methanol was added 1.0 gm (4.76 mMol) 5-methanesulfonylamino-1H-indole followed by 0.76 mL (6.2 mMol) 1-methyl-4-piperidone. The homogeneous solution was heated to reflux for 18 hours under nitrogen. The reaction mixture was then cooled and concentrated under reduced pressure. The residue was dissolved in water and the pH of the solution adjusted from 14 to 8-9 by the addition of acid. The precipitate that formed was filtered, washed with water and dried under vacuum to give 1.3 gm (89.6%) of the title compound as a tan solid.

1. temperatureThe homogeneous solution was heated
2. temperatureto reflux for 18 hours under nitrogen
3. temperatureThe reaction mixture was then cooled
4. concentrationconcentrated under reduced pressure
5. dissolutionThe residue was dissolved in water
6. additionthe pH of the solution adjusted from 14 to 8-9 by the addition of acid
7. customThe precipitate that formed
8. filtrationwas filtered
9. washwashed with water
10. customdried under vacuum