1-(Isopropyl)-4-piperidone → HCID 22611319, compound

HRID 1737726Notes

Reaction equation

HRID 1737726 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[CH:9]2)(=[O:4])=[O:3].[CH:15]([N:18]1[CH2:23][CH2:22][C:21](=O)[CH2:20][CH2:19]1)([CH3:17])[CH3:16]>>[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[C:9]2[C:21]1[CH2:22][CH2:23][N:18]([CH:15]([CH3:17])[CH3:16])[CH2:19][CH:20]=1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 793131-(Isopropyl)-4-piperidoneHCID 10036020HCID 10036020, compound

Product 1

HCID 22611319HCID 22611319, compoundYield 64.3%

Procedure

Beginning with 1.0 gm (4.76 mMol) 5-methanesulfonylamino-1H-indole and 0.873 gm (6.2 mMol) 1-isopropyl-4-piperidone, 1.02 gm (64.2%) of the title compound were recovered as a tan powder.

Sources & evidence

ORD record
ord-68711cf85e7744edaa3a145fb749e435
Source dataset
uspto-grants-1999_10
Patent number
US05962474

Reaction notes

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