4-Chlorobenzoyl chloride → HCID 22611445, compound

HRID 1737757Notes

Reaction equation

HRID 1737757 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=1.[Cl:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[C:11]2[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=2)=[O:24])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 111488671H-Indol-5-amine, 3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-

Product 1

HCID 22611445HCID 22611445, compoundYield 29.9%

Procedure

Beginning with 1.13 gm (5.0 mMol) 5-amino-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and 0.64 mL (5.0 mMol) 4-chlorobenzoyl chloride, 0.544 gm (29.9%) of the title compound were recovered as a tan solid.

Sources & evidence

ORD record
ord-0f171a753c9a49c399d0a7be61024548
Source dataset
uspto-grants-1999_10
Patent number
US05962474

Reaction notes

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