3-(Dimethylamino)benzoic acid → HCID 22611617, compound

HRID 1737800Notes

Reaction equation

HRID 1737800 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH3:18][N:19]([CH3:29])[C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23](O)=[O:24]>>[CH3:18][N:19]([CH3:29])[C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:24]

Participants

3

Reactant 2

HCID 668373-(Dimethylamino)benzoic acidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611617HCID 22611617, compound

Procedure

Reacting 12.0 mg (0.05 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole with 17.0 mg (0.10 mMol) 3-(dimethylamino)benzoic acid at 70° C., 12.4 mg (66%) of the title compound were recovered.

Workup

  1. customat 70° C.
  2. custom12.4 mg (66%) of the title compound were recovered

Sources & evidence

ORD record
ord-d0316684b16e4a75919579120c04e144
Source dataset
uspto-grants-1999_10
Patent number
US05962474

Reaction notes

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